NAD+ has emerged as one of the most researched molecules in anti-aging science. This coenzyme, found in every cell of your body, plays a critical role in energy metabolism, DNA repair, and cellular signaling. As we age, NAD+ levels naturally decline — and researchers are exploring whether restoring these levels can slow or reverse aspects of aging.
NAD+ molecular structure - essential coenzyme
Mitochondria - where NAD+ powers cellular energy
NAD+ is found in every cell of your body
What is NAD+ and Why Does It Matter?
NAD+ at a Glance
- •Full Name: Nicotinamide Adenine Dinucleotide
- •Type: Cellular coenzyme essential for metabolic and signaling reactions
- •Location: Found in every cell of the human body
- •Key Functions: Energy production (ATP), DNA repair, cellular signaling
Metabolomics-based studies have identified NAD+ as a central metabolic intermediate linked to many of the hallmarks of aging. It serves as a crucial substrate for enzymes called sirtuins, which regulate cellular health, inflammation, and longevity pathways.
Research has documented an age-dependent decrease of cellular NAD+ across multiple species. In humans, this decline has been observed in the liver, skin, brain, plasma, skeletal muscle, and immune cells — correlating with many age-related health changes.
The Science: How NAD+ Declines With Age
Animal Research Findings
In mice, NAD+ levels decrease approximately twofold by mid-age. When researchers successfully restored NAD+ to youthful levels, they observed cardiovascular improvements, reversal of metabolic conditions, improved muscle function and endurance, and increased mitochondrial function with ATP production.
Human Research
A 2025 study in 46 older adults with cognitive decline found that NAD+ precursor supplementation led to a 7% reduction in phosphorylated tau — a biomarker associated with Alzheimer's disease. This suggests potential neuroprotective effects.
2024 Breakthrough Discovery
A groundbreaking 2024 study provided the first compelling evidence that NAD+ can directly enter cells through specialized channels called connexin 43 hemichannels. Previously, scientists believed NAD+ had to be broken down into precursors before cellular uptake — this discovery opens new possibilities for direct NAD+ therapy.
Potential Benefits of NAD+ IV Therapy
Cellular Energy Production
NAD+ is essential for mitochondrial function and ATP synthesis — the energy currency of your cells. Higher NAD+ levels may support improved energy and reduced fatigue.
DNA Repair Support
NAD+ activates PARP enzymes that repair damaged DNA. This repair mechanism becomes increasingly important as we age and accumulate more DNA damage.
Cognitive Function
Research suggests NAD+ may support brain health and cognitive function. Studies show potential benefits for focus, mental clarity, and neuroprotection.
Muscle Recovery
Animal studies show NAD+ supplementation improves muscle function and endurance. This may translate to faster recovery and better physical performance.
IV Administration vs. Oral Supplements
One of the key questions in NAD+ therapy is the delivery method. Here's what current research tells us about the differences:
| Factor | IV Administration | Oral Precursors (NR/NMN) |
|---|---|---|
| Bioavailability | 100% enters bloodstream directly | Variable, depends on gut absorption |
| Speed of Effect | Immediate blood level increase | Gradual over hours/days |
| Duration | Rapid clearance observed in studies | Sustained with daily dosing |
| Convenience | Requires professional administration | Daily capsules at home |
| Research Base | Limited clinical trials | More human studies available |
Important Research Note
A pilot study found that after a 6-hour NAD infusion, plasma NAD levels didn't begin to rise until after two hours, with increased urinary excretion at six hours — suggesting the body may clear IV NAD+ relatively quickly. This is an active area of research, and optimal dosing protocols are still being developed.
What to Expect from NAD+ IV Therapy
Pre-Treatment Consultation
Our medical team reviews your health history, current medications, and treatment goals to ensure NAD+ therapy is appropriate for you.
Infusion Process
NAD+ infusions typically take 2-4 hours depending on the dosage. The slow infusion rate helps minimize potential side effects like flushing or nausea.
During Treatment
You may experience warmth, slight flushing, or mild nausea — these are common and usually subside when the drip rate is adjusted. Most clients read, work, or relax during treatment.
Post-Treatment
Many clients report feeling more energized and mentally clear after treatment. Some benefits may develop over the following days as cellular processes are supported.
Who May Benefit from NAD+ Therapy?
Common Reasons for NAD+ Therapy
- ✓Adults over 40 interested in cellular health optimization
- ✓Those experiencing chronic fatigue or low energy
- ✓Individuals seeking cognitive performance support
- ✓Athletes wanting enhanced recovery
- ✓Those on a proactive wellness and longevity protocol
Important Considerations
- !Research is still developing — NAD+ is not a proven anti-aging treatment
- !Individual results vary significantly
- !Should be part of a comprehensive wellness approach
- !Not recommended during pregnancy or for certain medical conditions
Safety Profile
Studies have shown that NAD supplementation, including IV NAD and nicotinamide riboside (NR), is generally well-tolerated and does not produce serious adverse effects when used as directed by trained medical professionals.
Common temporary side effects during infusion may include:
Flushing
Warmth sensation
Mild Nausea
Usually temporary
Chest Tightness
Rare, rate-dependent
Lightheadedness
Typically brief
These effects are typically managed by adjusting the infusion rate. Our medical team monitors you throughout the treatment to ensure comfort and safety.
Interested in NAD+ IV Therapy in Bali?
Our licensed medical team offers NAD+ infusions at your villa, hotel, or accommodation. Contact us for a consultation to discuss if NAD+ therapy is right for you.
Inquire About NAD+ Therapy